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Sample Question Which of the following options is a target for deep brain stimulation (DBS) in the treatment of Parkinson’s disease?
- Caudate nucleus
- Globus pallidus interna
- Internal capsule
- Subcallosal cingulate
- Vagus nerve
Key Learning Point: The primary targets for deep brain stimulation in the treatment of Parkinson’s disease are the subthalamic nucleus and globus pallidus interna.
Explanation: Deep brain stimulation (DBS) is a treatment option for Parkinson’s disease. The two main sites for DBS in Parkinson’s disease are the subthalamic nucleus and globus pallidus interna. The subcallosal cingulate was initially investigated as a potential target for DBS in the treatment of treatment-resistant depression (TRD). Vagal nerve stimulation has also been utilized for TRD. Targeting the anterior limb of the internal capsule is a neurosurgical treatment for refractory obsessive-compulsive disorder (OCD) and TRD. Although associated with Parkinson’s disease, the caudate nucleus is not a primary treatment target for DBS.